Methylated DNA Sensor Detects Cancer
Prof. Amir Saheb, a GT Ph.D. alumni and Dr. Ehsan Najafabadi, who graduated last summer from Prof. Bernard Kippelen’s lab at GT, have collaborated to commercialize aspects of Prof. Saheb’s graduate and professorial research. This DNA chip has 16 sensors capable of detecting up to 16 types of cancer in one pass using novel electrochemical ‘fingerprints.’ Cancer cells have specific methylated gene patterns. These epigenetic traits can be measured by this sensor with extremely high specificity. This means that in diagnostic tests, such as the PSA, (which looks for prostate cancer) false positives could potentially be reduced by an order of magnitude.